Science

Emmanuelle Charpentier

RNA and CRISPR researcher

Also known as E. Charpentier

Who they are

Emmanuelle Charpentier was a corresponding author of the 2012 study showing how RNA guides Cas9 to selected DNA. The collaboration included Jennifer Doudna, Martin Jinek and other researchers. Its engineered single-guide experiments demonstrated programmable cleavage in vitro and proposed a route toward genome editing.

Her contribution belongs to the timeline’s history of molecular tools and biological understanding.

Selected contributions

Coauthored the 2012 RNA-guided Cas9 study and served as a corresponding author.Source ↗

Selected works

Academic paper · 2012 · Peer-reviewed article; author manuscript
A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity
Coauthor and corresponding author · Science; author manuscript hosted by UC Berkeley eScholarship
Jinek and colleagues explain RNA-guided Cas9 cleavage and test an engineered single guide against DNA in vitro. The paper presents programmable genome editing as a possible application, rather than an already demonstrated therapy.
Science article published online June 28, 2012; issue date August 17, 2012.
Full text ↗
Reading scope & citation
Reuses documented prior inspection: Specific mechanism, engineered-guide, conclusion and byline passages inspected; supplementary experiments not comprehensively reviewed. Reuses the input’s documented prior inspection: Specific mechanism, engineered-guide, conclusion and byline passages inspected; supplementary experiments not comprehensively reviewed. No fresh full-work reread in this directory pass. Fresh first-page byline, equal-contribution note, affiliations, abstract and repository metadata read; earlier documented mechanism/conclusion inspection reused. Supplements not audited.