Science

Jennifer Doudna

Biochemist and CRISPR–Cas9 researcher

Also known as Jennifer A. Doudna · J. A. Doudna

Who they are

Jennifer Doudna was a corresponding author of the 2012 collaborative study that demonstrated RNA-directed Cas9 cleavage and an engineered single guide. The work connected molecular understanding of a bacterial defence mechanism with a potential tool for choosing DNA targets. Her role belongs within the full team rather than replacing the other authors’ contributions.

She appears in the timeline through the biochemical step toward programmable genome editing.

Selected contributions

Served as a corresponding author on the Jinek-led Cas9 study.Source ↗
Coauthored the study reporting engineered-guide cleavage in vitro.Source ↗

Selected works

Academic paper · 2012 · Peer-reviewed article; author manuscript
A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity
Coauthor and corresponding author · Science; author manuscript hosted by UC Berkeley eScholarship
Jinek and colleagues explain RNA-guided Cas9 cleavage and test an engineered single guide against DNA in vitro. The paper presents programmable genome editing as a possible application, rather than an already demonstrated therapy.
Science article published online June 28, 2012; issue date August 17, 2012.
Full text ↗
Reading scope & citation
Reuses documented prior inspection: Specific mechanism, engineered-guide, conclusion and byline passages inspected; supplementary experiments not comprehensively reviewed. Reuses the input’s documented prior inspection: Specific mechanism, engineered-guide, conclusion and byline passages inspected; supplementary experiments not comprehensively reviewed. No fresh full-work reread in this directory pass. Fresh first-page byline, equal-contribution note, affiliations, abstract and repository metadata read; earlier documented mechanism/conclusion inspection reused. Supplements not audited.